Science at PRBB: Roberto Elosua’s group on cardiovascular epidemiology and genetics

The Cardiovascular epidemiology and genetics research group, led by Roberto Elosua and Jaume Marrugat at the IMIM, tries to identify the incidence of cardiovascular diseases, their determinants and evaluate prevention strategies. In this short video, Dr Elosua explains their research … Continue reading Science at PRBB: Roberto Elosua’s group on cardiovascular epidemiology and genetics

Therapeutic virus-like particle- based vaccines against cervical cancer

Cervical cancer represents the second most frequent gynecological malignancy in the world. It is caused by a persistent virus infection by the high-risk human papillomavirus (HR-HPV) but no cervical cancer vaccine has been marketed to date. In a paper published in PLoS, Juan Martin Caballero, director of the PRBB animal facility, together with colleagues from a pharmaceutical company have generated a virus-like particle (VLP)-based vaccine to treat this cancer and have tested it in humanized transgenic mice. The researchers took a long C-terminal fragment of the HPV-16 E7 protein – one of the two viral proteins necessary for induction and maintenance of malignant transformation – … Continue reading Therapeutic virus-like particle- based vaccines against cervical cancer

Challenges and limitations of Bioinformatics: XI Bioinformatics Symposium at the PRBB

More than 225 people registered to the XI Bioinformatics Symposium, co-organised by the Spanish Institute of Bioinformatics (INB) and the Portuguese Bioinformatics Network and hosted by the PRBB. From yesterday, January 23 and until tomorrow, Jan 25 they will enjoy the talks of three keynote speakers and another 31 scientists, as well as more than 100 scientific posters. Alfonso Valencia, director of the INB – and who had recently been at the PRBB for another bioinformatics meeting – explained at the inauguration that the aim of the conference, organized jointly with the Portuguese community for the last three years, was to stimulate collaborations between both countries … Continue reading Challenges and limitations of Bioinformatics: XI Bioinformatics Symposium at the PRBB

The PRBB consolidates its internationalization

Take a look at the new issue of Ellipse, the monthly bilingual publication of the PRBB. We have now reached 50 editions!!!! Check out how the demography of the PRBB has changed over the last 5 years, to reach 50 different nationalities amongst our 1,345 residents. Actually, currently 41% of the researchers at the park are non-Spanish! How does the biological clock controls skin stem cell activation? And did you know the ‘out-of-Africa’ route was through Arabia, and not Egypt? CRG researchers show how it is possible to predict the phenotype from individual genomes; an international group of scientists ask … Continue reading The PRBB consolidates its internationalization

How does genotype determine phenotype?

Very interesting talk by Edward Marcotte today at the PRBB! He is an expert in proteomics, but touches all aspects of systems biology, and today he asked the following question: how does genotype determine phenotype? Can we predict the outcome of all the genomic variation we are uncovering with the many genomic projects we are doing nowadays? Well, his lab is certainly trying to do so, and using three different strategies which I will summarise very briefly: 1.  Using functional gene networks, which are based on data such as mRNA expression, protein-protein interactions (PPI), etc. These networks presumably are formed … Continue reading How does genotype determine phenotype?

“Insights from proteomics into cellular evolution and surprising disease models”

Don’t miss Edward Marcotte‘s talk next week at the PRBB!! Coming from the Institute for Cellular and Molecular Biology (ICMB) at the University of Texas at Austin, USA, Marcotte will give a talk entitled “Insights from proteomics into cellular evolution and surprising disease models” next Tuesday November 22 in room 473.10 at 12h. He has been invited by Gian Gaetano Tartaglia (CRG). Marcotte works in systems and synthetic biology, studying the large-scale organization of proteins. He tries to reconstruct the ‘wiring diagrams’ of cells, learning how all proteins are associated into pathways, systems, and networks. He is interested both in discovering … Continue reading “Insights from proteomics into cellular evolution and surprising disease models”

How to integrate your experimental data in a nice image

SVGmap is a configurable image browser for experimental data, a  new tool developed by the biomedical genomics group of the GRIB (UPF-IMIM) at the PRBB. According to the group “it is useful to create browsers for individualized high-quality images which change the color of some regions according to some values”.  It has recently been published in Bioinformatics. You can read more about it at Núria López-Bigas’ laboratory blog: http://bg.upf.edu/blog/ Continue reading How to integrate your experimental data in a nice image

CRG Symposium “Computational Biology of Molecular sequences”, part 3

On the second day of the conference, some more interesting talks at the “Computational Biology of Molecular sequences” X CRG Symposium taking place at the PRBB Conference Hall. I will focus on one talk of each of the sessions (genome regulation, RNA analysis and genome annotation), although all were very interesting! Ron Shamir (Tel Aviv University) presented Amadeus, a software platform for genome-scale detection of known and novel motifs in DNA sequences, and explained some of the findings they have done with it. He also presented his new book “Bioinformatics for biologists”, which will surely be very useful for many biologists drowning … Continue reading CRG Symposium “Computational Biology of Molecular sequences”, part 3