Challenging the model: transcription without the canonical histone marks

A guest post written by Silvia Perez Lluch, from Roderic Guigó’s laboratory at the CRG. You can find more about her career and work here. Transcription is a process that depends on many elements such as transcription factors, DNA methylation and chromatin structure. Histones are essential for the proper regulation of transcription, and the posttranslational modifications on their tails have been related both to activation (H3K4me3, H3K9ac and H3K36me3) and silencing (H3K27me3 and H3K9me3) of gene expression. Using the fruit fly as model organism, in our lab at the CRG and in collaboration with Montserrat Corominas’ lab in the Universitat de … Continue reading Challenging the model: transcription without the canonical histone marks