“It’d like to understand the real nature of B-cell diversity”

An interview published in Ellipse, the monthly magazine of the PRBB. Andrea Cerutti is a 44-year old Italian ICREA research professor who joined the IMIM in 2010, after moving from Padua to New York. Here he leads the B-cell laboratory in parallel with his former lab at the Mount Sinai School of Medicine in New York. As an immunologist he aims to understand the basic principles underlying B-cell functions leading to the diversification of antibodies.   Why did you come to Spain?  After 14 years in the USA coming to Spain was not only a scientific, but also a very personal … Continue reading “It’d like to understand the real nature of B-cell diversity”

A new type of neutrophils with a role in antibody production

Following on a previous post on a review on the regulation of mucosal IgA responses by Andrea Cerutti, we are back with this IMIM researcher, who has now published a paper in Nature Immunology. His group, in collaboration with scientists in Mount Sinai in New York, has just discovered the presence of neutrophils in the marginal zone (MZ) of the spleen, a B cell area positioned at the interface between the circulation and the immune system. The presence of these cells is constant, even in the absence of infection. The authors obtained lymphoid organs from people with no inflammation or infection. … Continue reading A new type of neutrophils with a role in antibody production

Regulation of mucosal IgA responses (review)

Andrea Cerutti (corresponding author) from IMIM-Hospital del Mar has just published a review on the regulation of mucosal IgA responses in the journal Ann. N.Y. Acad. Sci. The intestinal mucosa has evolved several strategies to control microbic commensals and neutralize pathogens without causing inflammatory damage to the epithelial barrier. One of these strategies involves the production of massive amounts of IgA, the most abundant antibody isotype in our body. The review puts together scientific evidence on  the mechanisms by which mucosal B cells undergo IgA diversification and production and discusses how the study of primary immunodeficiencies facilitates better understanding of … Continue reading Regulation of mucosal IgA responses (review)