Therapeutic virus-like particle- based vaccines against cervical cancer

Cervical cancer represents the second most frequent gynecological malignancy in the world. It is caused by a persistent virus infection by the high-risk human papillomavirus (HR-HPV) but no cervical cancer vaccine has been marketed to date. In a paper published in PLoS, Juan Martin Caballero, director of the PRBB animal facility, together with colleagues from a pharmaceutical company have generated a virus-like particle (VLP)-based vaccine to treat this cancer and have tested it in humanized transgenic mice. The researchers took a long C-terminal fragment of the HPV-16 E7 protein – one of the two viral proteins necessary for induction and maintenance of malignant transformation – … Continue reading Therapeutic virus-like particle- based vaccines against cervical cancer

New animal models for biomedical and biotechnology research: The zebrafish

Juan Martín-Caballero at the Barcelona Biomedical Research Park animal facilities – Photo: © Diario Médico The zebrafish (Danio rerio) is frequently used in drug discovery and key aspects of developmental biology. Mostly because of its quick development time (its organs are fully formed after just 48 hours) and transparent embryos. Above all, in research into regenerative medicine, because the fish is able to regenerate part of its caudal fin or, even, more than half of its heart. One of the main lines of research carried out with this animal model is that to discover the genes involved in regenerative processes. … Continue reading New animal models for biomedical and biotechnology research: The zebrafish