In her latest post, Mar Albà, head of the Evolutionary genomics lab at the UPF-IMIM, explains her group’s research into new genes and their role in mammalian-specific adaptations. You can read the paper she refers to in bioRxiv, the preprint server for biology! “Many human genes have counterparts in distant species such as plants or bacteria. This is because they share a common origin, they were invented a long time ago in a primitive cell. However, there are some genes that do not have counterparts in other species, or only in a few of them. These genes have been born much more … Continue reading New genes and functional innovation in mammals
Cedric Notredame, a group leader at the CRG, tells us in his “Slow bioinformatics blog” his personal and interesting story behind the development of T-coffee, a method for multiple sequence alignment which he developed during his PhD and which is … Continue reading T-Coffee Reloaded
The World Antibiotic Awareness Week took place last 14-20 November, and the Antibiotic Resistance Initiative ISGlobal team took the chance to explain to the world what are the main difficulties on the fight against antibiotic resistance – a serious problem that … Continue reading The four battlefronts in the war against Antibiotic Resistance
Ribosome profiling is a sequencing technique that detects regions in mRNAs that are being translated. Using this technique, researchers have observed mysterious patterns of translation in many transcripts believed to be non-coding (lncRNAs, or long non-coding RNAs). The patterns are very similar to those observed in protein-coding genes but the translated proteins are generally smaller. Aside from their sequence, we know nothing about these peptides. Are they functional? Do they reflect some background noise of the translation machinery? You can get some insights from a a recent study published in bioRxiv by the group led by Mar Albà at the … Continue reading Pervasive translation of lncRNAS
Núria López-Bigas started her lab on Computational Oncogenomics at the GRIB, within the PRBB, ten years ago. After a very successful decade, we are sad to see her leaving. We wish her all the best in her lab’s new adventure, and we hope the very fruitful interactions she has started with the different groups at the park will continue to prosper. In her last post on her blog, Núria says thanks to the GRIB, the UPF, the PRBB community and the PRBB Intervals programme… We want to say, thanks to you Núria, for the great research you have done and for … Continue reading See you soon, Computational Oncogenomics lab!
Guillaume Filion’s latest post is aimed at those wanting to understand the details of how the Burrows–Wheeler transform (an algorithm used in data compression) works. It may be of particular interest to those genomics researchers working on alignments, since, Filion says, the Burrows-Wheeler indexing is used to perform the seeding step of the DNA alignment problem, and it’s exceptionally well adapted to indexing the human genome. For those of you who are not afraid of the small mathematical details, you can see this “The grand locus” post here. Continue reading A tutorial on Burrows-Wheeler indexing methods
In this recent post by the HealthISglobal blog, Margarita Triguero, a PhD student at CREAL (now part of ISGLobal), gives us an overview about some recent studies showing the effects of natural spaces – mostly green spaces, both big and small … Continue reading Contact With Natural Spaces Improves the Health of the Population
Citizen Science is blooming. There’s a growing number of examples of research projects in which the general population can participate. In this post at the blog Health ISGlobal, the researcher Irene Eleta (CREAL) talks about some of these projects which are related to air pollution and that scientists at CREAL /ISGlobal are leading, such as CITI-SENSE. Continue reading Science for All and All for Air Quality
Congratulations to Núria López-Bigas at the GRIB (UPF-IMIM) for her lab’s latest paper in Nature describing why there’s an increased mutation rate in Transcription Factor Binding Sites (TFBS) in melanomas and lung tumors!!!! You can read more about the experience publishing this paper in this post from her lab’s blog, where she explains how, after a long process of reviewing, they felt they “had the responsibility to describe our finding as soon as possible to the community”, and decided to publish the manuscript in bioRxiv. Later on, the paper was accepted and published by Nature. Here’s for this success story! You can read the paper … Continue reading Proteins bound to DNA impair Nucleotide Excision Repair
“You went to high school and you learned genetics. You heard about a certain Gregor Mendel who crossed peas and came up with the idea that there is a dominant and a recessive allele. You did not particularly like the guy … Continue reading Did Mendel fake his results?