The alternative ways of cancer

 

It has been long recognized that disruption of splicing mechanisms can cause disease, including cancer. The Computational RNA Biology research group led by Eduardo Eyras at the GRIB (UPF:IMIM) has recently performed an exhaustive analysis of the functional impacts produced by alternative splicing changes in tumors (Climente-Gonzalez et al. 2017). They found that cancer specific alternative splicing changes lead frequently to shorter protein products and sometimes to a non-coding transcript.

You can read more about this latest paper in their latest group’s blog entry.

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