Assessing a new test for cervical cancer

Continuing with the issue of cervical cancer (you can read a previous post about virus-like particle (VLP)-based vaccines against this type of cancer), which is caused by high-risk human papillomavirus (HR-HPV), a group of researchers from the Pathology department of the Hospital del Mar (Parc de Salut MAR Biobanc), a reference laboratory for cervical cytology in Barcelona, have recently evaluated the clinical performance of a new HPV test (the cobas HPV Test). Although the most widespread screening technique for cervical cancer is cytology (also called Papanicolaou test, or Pap smear), HPV detection has been proposed as an alternative, since it is more sensitive for the detection … Continue reading Assessing a new test for cervical cancer

Therapeutic virus-like particle- based vaccines against cervical cancer

Cervical cancer represents the second most frequent gynecological malignancy in the world. It is caused by a persistent virus infection by the high-risk human papillomavirus (HR-HPV) but no cervical cancer vaccine has been marketed to date. In a paper published in PLoS, Juan Martin Caballero, director of the PRBB animal facility, together with colleagues from a pharmaceutical company have generated a virus-like particle (VLP)-based vaccine to treat this cancer and have tested it in humanized transgenic mice. The researchers took a long C-terminal fragment of the HPV-16 E7 protein – one of the two viral proteins necessary for induction and maintenance of malignant transformation – … Continue reading Therapeutic virus-like particle- based vaccines against cervical cancer

Environmental exposures and child health – a new European study

The official kick-off of the HELIX project (The Human Early-LIfe Exposome) will be taking place on March 11-13 at the PRBB, with public conferences in the Auditorium on the first day. Coordinated by Martine Vrijheid from CREAL, HELIX has received €8.6M from the European Commission’s 7th Framework Programme. It aims to build an early life “Exposome”, a collection of all early-life environmental exposures affecting children, and it has 4 years and a half, from January 2013 to July 2017, to do so. HELIX will develop tools to measure the exposome, including the use of smartphones and biological markers. The project involves 13 partners from eight … Continue reading Environmental exposures and child health – a new European study