Pedro Carvalho (CRG) explains the role of ER in protein control and lipid homeostasis

Pedro Carvalho, from the CRG tries to understand how the cell uses its quality control mechanisms to get rid of proteins that are not functional. He also studies lipid homeostasis. Both functions take place at the Endoplasmic Reticulum (ER). Check … Continue reading Pedro Carvalho (CRG) explains the role of ER in protein control and lipid homeostasis

Changes in the brain in patients with ADHD

Attention-Deficit/Hyperactivity Disorder ADHD involves robust alterations in the cortical cerebral mantle, as shown in a recent article by Òscar Vilarroya and colleagues from the Neuroimaging Research Group at the IMIM-Hospital del Mar. These alterations are most prominent in brain regions involved in attention processing, and are more common in the childhood form of the disorder than in the adult one. ADHD is a psychiatric and neurobehavioral disorder characterized by either significant difficulties of inattention or hyperactivity and impulsiveness or a combination of the two. Although it was initially regarded as a disorder exclusive to childhood – affecting about 3 to 5 percent of children globally -, nowadays its prevalence in adulthood is … Continue reading Changes in the brain in patients with ADHD

Down syndrome hippocampal defects improved in a mouse model

In a recent work published in Neurobiology of disease, the research groups lead by Mara Dierssen at the CRG and Cristina Fillat, now at the August Pi i Sunyer Biomedical Research Institute (IDIBAPS) have joined efforts to find a potential therapeutic target for Down Syndrome (mice). Down Syndrome (DS), caused by the trisomy of human chromosome 21 (HSA21), is the most common chromosome abnormality in humans. It is typically associated with a delay in cognitive ability, with an average IQ of around 50 in young adults compared with 100 in adults without the condition, as well as with physical growth and a particular set of facial characteristics. The Ts65Dn mouse is a genetic model … Continue reading Down syndrome hippocampal defects improved in a mouse model