Coloring the formation of the skeleton

Coloring the formation of the skeleton

During the endochondral bone formation of vertebrates, the mesenchyme condensates and gives rise to cartilage which eventually is replaced by bone. In the picture performed by Ulrike Brandt-Bohne from the Genes and Disease Department of the CRG the bones of a newborn mouse are stained pink and the cartilages which are not ossified stained blue with an Alcian Blue/Alzizarin Red Skeletal Staining procedure. The aim of this staining was to visualize the skeletal structure of WT (wild type) versus mutant mouse models in order to detect changes in the skeletal morphology.

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We lead biomedical translational research in Southern Europe

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