Moving in, moving out

With more than 1,400 people working at the PRBB, the movement of researchers coming and going is constant. One of the most recent acquisitions is Eduard Sabidó, who has just arrived to be the new head of the CRG/UPF Proteomics Unit. Eduard is coming from the Swiss Federal Institute of Technology of Zurich (ETHZ)  and will be leading this core facility which offers service to the whole park and beyond. A new young group leader has also joined the CRG recently. The French molecular biologist Guillaume Filion (who, as we mentioned in an earlier post, is currently looking for a postdoc) was … Continue reading Moving in, moving out

Helping 3′ splice site recognition

Splicing is a complex mechanism that generates mature mRNA from pre-mRNA and which is essential for a correct gene expression. It involves many factors – nearly 400, if we consider alternative splicing as well – and it is tightly controlled. A new paper published in Molecular Cell by Juan Valcárcel, head of the Regulation of Alternative pre-mRNA Splicing group at the CRG, and colleagues has now identified an heterogeneous nuclear ribonucleoprotein (hnRNP) that helps in the recognition of the 3′ splice site. The essential pre-mRNA splicing factor U2AF guides the early stages of splice site choice by recognizing a polypyrimidine … Continue reading Helping 3′ splice site recognition

EMBO meeting on yeast gene transcription

The EMBO meeting on “Gene transcription in yeast: from mechanisms to gene regulatory networks” aims to catalyze the transformation of the field from classical genetics, biochemistry and structural biology to functional genomics and molecular systems biology of gene transcription and regulation. Organised by Francesc Posas, the director of the Department of Experimental and Health Sciences of the UPF, the meeting will take place in Girona on June 16-21, 2012. However, registration deadline is already on March 16, so don’t wait too long! You can already check out the programme on the conference website. Make sure you don’t miss this opportunity! Continue reading EMBO meeting on yeast gene transcription

The February issue of Ellipse is out

In the 51st edition of El·lipse, The Pasqual Maragall Foundation for Alzheimer’s research announces the location of its new building, a few meters from the PRBB. Xavier Nogués (IMIM) talks about his research on osteoporosis while Jean Michel Claverie, from the CNRS, tells us about his discovery of mimiviruses. Other news include articles on why a bit of stress can be protective for your cells; the existence of spleen neutrophils; how the fate of embryonic stem cells is controlled; new targets against Duchenne dystrophy; and the discovery of new anti-angiogenic compounds. Also, how does temperature control sex? And what are … Continue reading The February issue of Ellipse is out

Meeting on Systems biology of Drosophila development – register now!

Johannes Jaeger, from the CRG, is the chair of the ESF-EMBO Symposium “Systems Biology of Drosophila Development”, which will take place in May 21-25 in Poland. Co-chaired by Eileen Furlong, at the EMBL, the meeting will bring together experimentalists, computational biologists and theoreticians, who have made outstanding contributions to the study of Drosophila development. The aim is to enable researchers with different backgrounds and expertise to share their experiences and latest research, to discuss methodological issues, to identify problems with existing models, and to discuss new developmental processes, which would be worth studying using a systems-biology approach. Conference registration is … Continue reading Meeting on Systems biology of Drosophila development – register now!

Postdoc position on cell and molecular biology at the CRG

A postdoctoral position is available in the group of Pedro Carvalho at the CRG. The Organelle biogenesis and homeostasis lab studies the molecular mechanisms by which misfolded secretory and membrane proteins are detected and eliminated from cells. The succesful candidate will work on protein quality control. Application deadline is February, 29, 2012. Starting date would be no later than May 2012. Details: Postdoc position Continue reading Postdoc position on cell and molecular biology at the CRG

Bioinformatician position at the laboratory of Miguel Beato

Miguel Beato’s laboratory at the CRG on chromatin and gene expression is looking for a bioinformatician to give support to the members of the CONSOLIDER project “Epigenetic: Mechanisms and Disease”. The work would consist in developing and applying existing and newly developed bioinformatic and statistical tools to analyze genome-wide data (3C-derived methods, RNA-seq, ChIP-seq, MNase-seq, DNase I hypersensitive sites, CpG methylation and hydroxy-methylation assays) in cultured cells. Application deadline is February 20, 2012. Initial contract is for six months starting March 2012, with the possibility of extension into a more stable position. Details: Bioinformatician position Continue reading Bioinformatician position at the laboratory of Miguel Beato

Effects of chemical exposure and social environment on the developing brain

The developing brain is exceptionally sensitive to environmental influences, and two recent papers lead by scientists at the CREAL have analysed the effect of several variables – chemical exposure and social environment – in neurodevelopment of infants. In the specific cases studied, the effect didn’t seem to be very substantial. One of the articles was published in the American Journal of Epidemiology, and it focuses on the potential effect of prenatal exposure to mercury, since it is known that vulnerability of the central nervous system to this metal is increased during early development. The scientists examined 1,683 children who are … Continue reading Effects of chemical exposure and social environment on the developing brain

Polycomb switch in stem cell differentiation

The cover of the January issue of the journal Cell Stem Cell highlights the article: “Nonoverlapping functions of the polycomb group Cbx family of proteins in embryonic stem cells” by Luciano Di Croce and colleagues at the CRG. Although it is known that polycomb complexes (PRC) play an important role in the regulation of embryonic stem cell (ESC) pluripotency and early developmental cell fate decisions, this research has now shown that different Cbx protein compositions of the complex can modulate this regulation. In pluripotent cells, Cbx7 is the main PRC1-associated Cbx protein and is required to maintain the undifferentiated state in a … Continue reading Polycomb switch in stem cell differentiation

Genomic high-throughput sequencing data: what to trust

Does your research imply having to deal with a huge amount of high-throughput data? Are you worried about the interpretation of your Illumina sequencing data? Illumina’s Genome Analyzer (GA) and HiSeq instruments are currently the most widely used sequencing devices. If you use them or are thinking of using them, you might be interested in having a look at the latest paper coming from Heinz Himmelbauer and his colleagues at the CRG ultrasequencing unit and published in Genome Biology. Find out about the errors and biases they report to make sure your data analysis is of the highest quality! Reference: Minoche AE, … Continue reading Genomic high-throughput sequencing data: what to trust