In the early afternoon, genome evolution was still the focus of the talks at the X CRG Annual Symposium. Why do we care about reconstructing ancestral genomes? Apart from the fact that it’s difficult and fun (reasons enough for most computer scientists), according to Mathieu Blanchette (McGill University) it can help us to study the mechanisms of genome evolution and also for the identification of functional regions, such as TFBS. Blanchette also showed how to turn multiple sequence realignment into a game with Phylo http://phylo.cs.mcgill.ca/
Following on into genome regulation, Philipp Bucher (Swiss Institute of Bioinformatics) explained the workings of the Chip-seq technology and talked about the computational promoter analysis in the era of ultra-high-throughput sequencing. And to finish off the quite long day, Alfonso Valencia (CNIO) substituted Gene Myers (Janelia Farm), who regretfully couldn’t make it at the last minute. Valencia talked about open questions in the protein universe, such as: what proteins are in a cell? What protein complexes exist? How did protein families originated? And are we using the right tools and approaches to analyze pathways? Some may think that we know the answers to some of them, but Valencia showed otherwise…
More tomorrow! You can also check the rest of the program here.
Report by Maruxa Martinez, Scientific Editor at the PRBB