Analysing the Colon crypts

This image of a transversal cut of the colon shows the intestinal crypts stained with haematoxylin and eosin. The aim was to detect the presence of the activated IKK alpha protein (in brown). In healthy intestinal crypts such as those in the image, most of the cells are negative for this staining and the only brown cells are the lymphocytes that occupy the spaces in between the crypts. In colon tumour samples, on the other hand, there are high levels of activated IKK alpha in the cells of the crypt.

The image was taken by Vanessa Fernández-Majada and Lluís Espinosa, from the Stem cells and cancer research group of the IMIM, lead by Anna Bigas.

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